Job Scope:We are looking for a Supervisor of DNA Sequencing Lab as part of US Based, highly automated gene synthesis operations. The incumbent will work with the Director, Manager, staff research associate/technicians, and laboratory assistants in a multi-disciplinary manufacturing environment; supports in daily operation, maintenance, and systematic workflow of the DNA sequencing facility. The candidate in this position is responsible for training and supervision of laboratory assistants/technicians, coordinating with the relevant stakeholders in the manufacturing operations, and also sets up efficient scheduling of sequencing workflow for a minimum turnaround time. The position is also expected to help with the data analysis/bioinformatics of full DNA/plasmid sequencing data.Key Responsibilities:supervise the site sequencing personnel, equipment, materials and process to ensure stable and orderly daily productionThrough knowledge of Sanger and Next Generation Sequencing(NGS) workflow, preparing DNA sequencing samples by organizing and setting up sequencing reactions, schedule sequencing runs on DNA analyzersOptimize and perform cleanup of sequencing reactions, operations knowledge of automated liquid handlersLead sequencing team, track performance and participate in performance ratingAnalyze sequencing results, generate test reports, and give technical guidance to guide team membersEvaluate sequencing run results, and coordinate with data analysis groupImprove quality standards in sequence data generation, and lead key projects to continuously optimize sequencing workflowPerform instrument calibrations and regular maintenance including but not limited to DNA analyzers; acts as liaison with outside vendors relevant to sequencing instrumentsTroubleshoot instrument performance issues and make recommendations and/or adjustments to improve work efficiencyExecute SOP through training and supervision. Continuously optimize SOP to improve operational efficiencyTrain and supervise lab personnel's, troubleshoot failed or poor resultsKeep abreast with the latest advancement in sequencing technologies, develop new protocols for streamlined as well as to handle complex workflow, and provide suggestionsResponsible for team building and day to day management, including 5S, quality data generation, safety, and employee moraleOther tasks as assignedQualificationsBachelor's or Master's degree in Biology, Biochemistry, Molecular Biology. Chemistry or related fields2+ years of hands-on experience in DNA Sequencing platform(Sanger and/or NGS), analyzing DNA materials, sequencing workflow management, and data analysisGood understanding in the quantification and qualification methods of plasmid DNA, including spectrophotometric analysis, and electrophoresisTeam management experience is preferredMust have experience working in a high throughput manufacturing environment, and flexible to modification in work environmentStrong team management, communication and coordination skillsBasic knowledge of molecular biology required, knowledge in project management, 5S management, quality management systems are preferredExperience with automation tools is preferredHave a strong sense of work responsibility and cost awareness#GS#LI-LW1
