OverviewFred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.
With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.
At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.
The Post-Doctoral Research Fellow will work on independent and collaborative projects in Dr. Chapuis' laboratory developing adoptive T cell immunotherapy within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Center. This highly translational research will involve the development of novel TCR-based cellular therapies for clinical translation; development of next-generation humanized murine models to gain insights into the in vivo barriers to effective therapy; and may include monitoring patients throughout the course of treatment with T cell therapies. Additionally, the successful applicant will employ strategies for improving current immunotherapy treatments, including and not limited to cloning and characterizing T cell receptors (TCRs) specific for cancer-associated antigens, developing cutting-edge strategies for genetic modification of human T cells including CRISPR-based gene editing, and developing/testing new approaches for overcoming immunosuppressive signals in the tumor microenvironment.
Dr. Chapuis is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. This is a full-time position. Please note that WA state has mandated minimum salary for overtime-exempt employees (WAC ******** ).
ResponsibilitiesCell Culture, cell sorting, flow cytometry, intracellular staining, and transfectionsMolecular bench work with PCR, cloning, and vector designNGS including, Single cell RNA sequencing, WEX, WGSValidation through functional and killing assaysWrite and submit grants and first author papers to peer-reviewed journalsStay current with relevant publications and apply knowledge to researchCompile data and synthesize innovative problem-solving methodsCollaborate and present data with a wide range of stakeholders and partnersTrain others on protocolsMentor and lead undergraduate and graduate studentsAssist with lab maintenance and functionQualificationsMINIMUM QUALIFICATIONS: MD and/or a PhD in a biological science with a diverse knowledge of immunologyProficient in immunology technique and knowhowStrong scientific writing skills, ability to write and apply for funding opportunities and abstractsAble to digest complex material and synthesize innovative ideasCompile and clearly present data to an eclectic audience, both orally and writtenWell versed in flow cytometryPREFERRED QUALIFICATIONS: Experience with molecular techniques lentiviral modification of T cellsExperience in analysis of TCR signaling pathways and T cell functionFamiliarity with biostatistics, R and Python languagesAbility to derive and maintain T cell tissue culturesHave a good understanding of SRAs and/or phase I/II clinical trialsA statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists. The annual base salary range for this position is from $67,728 to $100,000 and pay offered will be based on experience and qualifications. Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, income-based child care subsidy, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (13 days per year), and paid parental leave (up to 4 weeks).
Our Commitment to DiversityWe are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance and/or a reasonable accommodation during the application or recruiting process, please send a request to Human Resources at ******** or by calling ******** .
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