Principal Scientist / Team Lead for Small Molecule Separation Apply locations San Diego - CA - US time type Full time posted on Posted 13 Days Ago job requisition id R1584733
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Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
This individual will be responsible for providing separation science support for the drug discovery/medicinal chemistry team at BMS in San Diego, CA. He or she will lead a team of scientists, including external service providers, to deliver non-GLP separation science support for the site. A particular focus will be managing a high throughput small molecule purification service, using both preparative liquid chromatography (HPLC) and preparative supercritical fluid chromatography (SFC), for achiral and chiral separations.
In addition to method development and purification, the candidate will provide limited on-site support for separation and physical property measurement, and will coordinate with team members at other sites to deliver capabilities not available locally. He or she will also ensure operational support of a fleet of analytical LCMS instruments used by medicinal chemists for routine reaction checking and compound QC.
He/she will work with other team members to ensure that the infrastructure is fully operational, to track usage and output metrics, to interact with medicinal chemists, and to troubleshoot problems as they arise. He/she will also work with the external service provider to ensure that scheduling and training are matched to requirements to ensure smooth and efficient operation of the lab.
In addition to the operational role described above, the individual will be responsible for working with management to develop, implement, and update the strategic plan for separation science at the site, and for identifying and completing continuous improvement projects that may include chromatography method development, infrastructure improvements, IT and process improvements, quality improvements, etc.
He or she will have experience in analysis and purification of small molecules and/or peptides by reverse phase HPLC and SFC, and in mass spectrometry. Experience in a high throughput environment managing large numbers of samples and associated data and/or experience in organic and medicinal chemistry is strongly desired. The candidate will have demonstrated problem-solving skills, including troubleshooting processes, instruments, and data management issues.
Expected competencies include: Strong written and oral communication skills Supervisory experience in a lab environment The successful candidate must be able to work independently and matrix across teams. Must have a proven record of accomplishment in successful project execution. The candidate will have demonstrated problem-solving skills, including troubleshooting workflows and processes, instruments, and data management issues. Basic Qualifications: Bachelor's Degree 8+ years of academic / industry experience or Master's Degree 6+ years of academic / industry experience or PhD 4+ years of academic / industry experience Preferred Qualifications: A Ph.D. degree in Organic or Analytical Chemistry and at least 4+ years of relevant industrial experience. Experience in a high throughput environment managing large numbers of samples and associated data. Experience in analysis and purification of small molecules and/or peptides by reverse phase HPLC and SFC, in mass spectrometry, and/or experience in organic and medicinal chemistry is a plus. The starting compensation for this job is a range from $121,000 - $167,200 plus incentive cash and stock opportunities (based on eligibility).
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