The Department of Epigenetics and Molecular Carcinogenesis is an interdisciplinary, basic science research department that conducts groundbreaking research aimed at defining the mechanisms controlling normal cell growth, proliferation, differentiation, and survival as well as mechanisms controlling genome maintenance to identify the aberrations in these processes that drive cancer.
Epigenetics and Molecular Carcinogenesis The Bedford Laboratory is defining the biological role of arginine methylation, a common post-translational modification present on histones and other proteins. Histone arginine methylation plays an important role in the histone code and epigenetic memory. The Bedford group focuses their research on protein arginine methyltransferases (PRMTs) that methylate arginine residues. Arginine is unique among amino acids as its guanidino group contains five potential hydrogen bond donors that are positioned for favorable interactions with biological hydrogen bond acceptors. Three types of methylarginine species exist: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). The formation of MMA, ADMA, and SDMA in mammalian cells is performed by a family of nine PRMTs.
KEY FUNCTIONS Research Support Plans, organizes, coordinates, directs and participates in scientific research projects. Determines specific goals or objectives to be attained, evaluates resulting research data and revises techniques or approaches to resolve problems and advance the project. Applies considerable scientific knowledge and experience in advancing the aims of the project. Presents findings and writes articles for publication. Expertise and Specialization Provides highly specialized skills, knowledge and/or expertise that is essential to the success of the project. Supervises the design, development or adapting of equipment used in experiments or research to obtain desired results. Develops innovative new approaches and/or new technology. Plans and supervises the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures. Laboratory Organization Responsible for oversight and supervision of the projects. Assigns/reviews work of subordinates working on the projects. Represents the lab at conferences and meetings. Reviews scientific findings/articles. Compiles, writes and submits reports to superiors. Writes grant proposals. May monitor project spending. EDUCATION Required: Masters degree in one of the natural sciences or related field.
Preferred: Medical degree or PhD in one of the natural sciences or related field.
EXPERIENCE Required: Four years of experience in experimental or scientific work. With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.
Additional Information Requisition ID: 170438 Employment Status: Full-Time Employee Status: Regular Work Week: Days Minimum Salary: US Dollar (USD) 66,500 Midpoint Salary: US Dollar (USD) 83,000 Maximum Salary: US Dollar (USD) 99,500 FLSA: exempt and not eligible for overtime pay Fund Type: Soft Work Location: Onsite Pivotal Position: Yes Referral Bonus Available?: No Relocation Assistance Available?: Yes Science Jobs: Yes
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