Company Overview Tango Therapeutics is a biotechnologycompanydedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at201 Brookline Avenue, inthe Fenway area of Boston, Massachusetts
Summary Reporting to the VP Program Management, this person will play an instrumental role in organizing and advancing critical portfolio programs, facilitating timely and impactful decisions, and contributing to the development of overall program strategy at Tango Therapeutics. This is an opportunity for a versatile individual to become an integral member of our R&D teams, further establishing the program management function as a key value driver for Tango Therapeutics. Together with program leaders (PL), this individual develops integrated drug discovery and development plans for the selection and progression of oncology clinical candidates into clinical development and registration. In this role you will ensure organizational alignment and oversee program execution at Tango and CROs, as well as foster team building and a collaborative environment.
Your Role: Leads program management activities for one or more small molecule cancer therapeutics through development candidate selection to clinical Proof of Concept (POC) and into full development and registrationSupports the PL and the discovery program team in the development of the program strategy for selection of the development candidate (DC) and progression into clinical development by planning and tracking activities in lead optimization, pharmacology, toxicology and ADME studies, preclinical work for patient selection and indication expansion, drug supply and formulation development and clinical planning and operationsGuides the development team through clinical development by creating and executing on an integrated clinical plan for POC and registration. Develops and assesses different scenarios for accelerated approval based on clinical outcomes from the first in human studies of the single agent and its combination with other targeted therapies. Works with sub-teams in manufacturing, clinical operations, safety, translational biology, regulatory and commercial to ensure that functional activities are fully integrated into the clinical development plan and support indication expansion and regulatory approvalAchieves organizational alignment and seamless execution of the integrated drug discovery and development plans by working cross-functionally within Tango and with CROsDefines critical path, at-risk activities, and inter-dependencies. Anticipates bottlenecks, clears barriers to progress program level scenario planning & risk managementRepresents, as needed, the program team to discussions with leadership teams, scientific founders, and DirectorsTracks program progress against the plan, working with department heads to identify and resolve resource constraints consistent with corporate prioritiesSupports active portfolio management (budget, resources, stage-gates) and decision-making and monitors progress of portfolio/program strategy, goals, and metricsEstablishes, together with the PL, program and individual goals that are aligned with corporate goalsSchedules, facilitates, and documents Program Team and ad-hoc program meetings; ensures uniformity between programs including agendas, meeting minutes and other program documentationIdentifies, tracks, and supports resolution efforts for all program-related issues. Relays positive and negative deviations from program plans to the program team and managementFacilitates resolution of conflicts between functional groups while maintaining objectivityEnsures high-performing project teams by monitoring and assessing team effectiveness at both team and individual levelsAdditional duties and responsibilities as requiredWhat You Bring: Bachelor's degree requiredMinimum of 10 years of relevant biotech or pharmaceutical industry experience is requiredMinimum of 3 years in a program management role requiredHands on experience in leading program management activities in early and/or full clinical development is requiredExperience in at least one of the functions related to pharmaceutical development (e.g. Research, Regulatory Affairs, Clinical Dev/Operations, CMC) is requiredExperience in oncology development is preferredMust demonstrate good leadership and team building skills, ability to influence cross-functionally, work with different personalities and styles and maintain positive interpersonal relationshipsExcellent written and verbal communication are essential, with the ability to clearly present and communicate complex program information in both formal and informal settingsStrong conflict resolution and problem-solving skills with an ability to handle complexity and ambiguityExperience with Risk Management and Contingency Planning preferredExperience setting and maintaining budgets preferredKnowledge of project management tools and software (MS Project, etc.)PMP certification a plusWe are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
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