Principal Scientist - Cardiometabolic Disorders

Join Amgen's Mission of Serving PatientsAt Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Principal Scientist - Cardiometabolic DisordersWhat you will doLet's do this. Let's change the world. We are building upon our solid Cardiovascular foundation and long-term dedication to patients by developing a whole new class of novel molecules – and we need top talent to ensure these molecules become medicines and realize their potential for helping patients. We are seeking a dedicated and highly motivated Principal Scientist to become a member of the Department of Cardiometabolic Disorders within Amgen Research located in Thousand Oaks, CA. In this vital and exciting role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients. The proposal and advancement of a drug discovery program will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies. Critical thinking, ingenuity, the ability to design and conduct mechanistic studies and deep biology, technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical toward advancing programs in the cardiometabolic pipeline. You will initially work at the bench conducting in vivo and/or in vitro preclinical studies with a focus on PAH, vascular disease and/or heart failure. Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research.
As part of the team, the candidate may also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio.
Conceptualizing and proposing therapeutic targets for the treatment of cardiometabolic diseaseDesigning and performing in vitro and cell-based experimentsIndependently performing data analysis and interpreting resultsCommunicating scientific results through written and oral presentationsCollaborating with teams from other functions in the company to advance our programsDocumenting work through written protocols, electronic laboratory notebooks and study reports.Advising colleagues in areas of expertiseWhat we expect of youWe are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications.
Basic Qualifications: Doctorate degree and 2 years of scientific experienceOr
Master's degree and 5 years of scientific experienceOr
Bachelor's degree and 7 years of scientific experiencePreferred Qualifications: PhD with postdoctoral experience in cardiometabolic disease (industry experience is strongly preferred)Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patientsExceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality dataTechnical mastery of general molecular biology, biochemical, and cell-signaling techniques including immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, and ELISABasic knowledge of statistical methods applied in a consistent and rigorous manner to all data sets generatedExcellent written and oral communication skills and interpersonal skills that enable effective team interactions and communication of key data to all key stakeholdersA strong ability to collaborate cross-functionally in a multidisciplinary environment is criticalCapability to deliver high quality manuscripts, posters and presentations for internal and external peer-reviewed publication and conference attendance.Understanding of human genetics and genomic data mining for target identification are a plus.What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models, including remote and hybrid work arrangements, where possibleApply nowfor a career that defies imagination Objects in your future are closer than they appear. Join us.
careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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