We believe the future of medicine lies within us.Fearless, inspired, connected…and awesomeThese are some of the words we use to describe ourselves and our culture. We are committed to a better future for patients, each other, and the community. We believe our role in making that a reality is as medical innovators, and the key to our success will be the power of our platform.
At Ensoma, we pride ourselves on being a team of entrepreneurs with trailblazer mindsets, fearlessly pushing the boundaries of science.
Vice President, Oncology
The way we work at Ensoma ignites the feeling of being part of a community, involved in something bigger than yourself.
Director, Downstream Process Development
Every piece of progress in our daily work at Ensoma is so rewarding because it could mean improving the quality of life of future patients by leaps and bounds
Associate Scientist III, Translational Science
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Our valuesInspired ActionWe push beyond today's possible. We take bold steps to turn complex ideas into elegant solutions. We are committed to a better future for patients, each other, and the community.
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Our valuesFearless DiscoveryWe are open, thoughtful, and relentlessly pursue the unknown to advance science. We learn from, teach, and challenge each other to break new ground.
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Our valuesFueled by ConnectionWe are a mighty team, each of us bringing valuable expertise and awesomeness. We are here to do our best work and elevate our impact together.
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"What if we…" are our favorite three words to start each day. Your every win is a win for us all. Every challenge is an opportunity to pitch in to everyone's benefit. We work to create an environment where trust and collaboration provide a foundation for innovation.We learn from, teach,and challenge each other to break newground. We are each here to do our best work but also to strive to elevate our impact together. Join us #InsideEnsoma .
We believe that the success of our company and employees goes hand in hand. Our generous and competitive benefits and wellness package play a critical role in supporting our team and their families. Ensoma offers a comprehensive package including medical, dental and vision coverage, life and disability insurance, 401(k), paid time off, and a year-end shutdown.
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being recognizedOpen positionsLocation: Boston, MA
Job Id:R101
# of Openings:1
Principal Scientist, Gene Editing
We are seeking a highly motivated and skilled Associate Director to join our Gene Editing team to develop innovative CRISPR-based therapeutics for treating diseases. You will work with colleagues from the protein engineering, biology, and early translation teams to develop and validate therapeutic strategies for CRISPR-based therapeutics. This position is ideal for a candidate with a passion for cutting-edge science and a desire to make a significant impact on Ensoma's therapeutic products as we seek to revolutionize treatments for patients with genetic diseases in the hemopoietic cell system.
Responsibilities: Conduct protein design activities, incorporating state-of-the-art approaches like structural biology and/or AIDesign and execute mid/high-throughput screening assays in bacterial settings to identify novel CRISPR-based editing systems and optimize their performance for treating diseases.Optimize and troubleshoot screening protocols to improve sensitivity, specificity, and reproducibility.Test selected editors in cell line and primary cellsAnalyze and interpret screening data (NGS) and communicate results to the project teamComplete laboratory experiments in timely fashion, including maintaining and producing a complete and accurate experimental recordsParticipate in scientific discussions with the rest of the organization and present recent findingsOther duties and responsibilities as assigned Qualifications:
Required:A Doctoral Degree in biochemistry, molecular biology or related field with a minimum of eight years of experience in the biotechnology/pharmaceutical industry and/or an academic setting (industry experience is preferred)Experience in protein design via structural biology and/or AI approachesExperience with experimental work using bacterial models e.g. Escherichia coliExperience with common DNA cloning techniquesExperience with cell biology and editing techniquesPreferred:Experience with Escherichia coli functional selections, directed evolution, or likewiseFamiliarity with programming (python, R, etc.), bioinformatics or protein structural analysisExperience with synthesis and/or handling of large variant DNA librariesExperience with CRISPR systems and gene editing About Ensoma:
Ensoma is a place where you can ask the big questions. We look at gene therapy today and ask: What if we could eliminate the patient burden? What if we could treat diseases that affect millions? What if we could treat people anywhere around the world?
Ensoma was founded to answer these questions through our Engenious platform that can transform the hematopoietic (blood & immune) system with a single treatment. Our Engenious gene therapy platform is the first to precisely engineer any or all hematopoietic and immune cells with a one-time, off-the-shelfin vivotreatment. Engenious therapies have an unmatched capacity to deliver all modern genetic modification tools and set a new standard for versatile cell programming and control across a range of complex diseases. We believe the future of medicine lies within us – and this bigger, bolder vision for gene therapy needs incredible people to make it a reality.
For our team, realizing this vision is personal. Founded and guided by leaders drawn from the top of the cell and gene therapy field, we feel an urgency and passion for our work driven by its potential global impact.
A meeting at Ensoma is a space where curiosity, trust, authenticity, problem-solving and professional development are celebrated. A career at Ensoma is an opportunityto be part of the team building the future of medicine.
Ensoma is a 5AM Portfolio company supported by top-tier investors, strategic partners, and a passionate team committed to a bold global vision for genomic medicines. Ensoma is headquartered in Boston, Massachusetts. For more information,please visit www.ensoma.com.
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