Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body's natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro's lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
Position Summary: Korro Bio is seeking a highly motivated Scientist to join our Platform Biology group and work with an enthusiastic team of highly skilled scientists. The ideal candidate for this lab-based position will have a strong background in RNA biology and demonstrated proficiency in driving cross-functional projects to completion. This is an exciting opportunity to be part of a collaborative team and contribute to the development of next-generation RNA editing technology and therapeutics in a fast-paced biotech company.
Key Responsibilities: Drive platform understanding through leading projects related to oligonucleotide-based therapeutic modalities (RNA editing, splicing, knockdown, etc).Capable of designing oligonucleotides to interrogate hypotheses aiming to improve mechanistic understanding, oligo potency and/or mitigate off target effects.Develop, validate and scale up novel molecular cellular assays to assess different aspects of oligo mediated RNA biology.Work effectively with disease area biology, data science, high-throughput screening teams and deliver high-quality results in a timely fashion.Support operations team in troubleshooting, equipment maintenance and CRO management.Accurately document project and sample information, protocols, and experimental details through an Electronic Lab Notebook (ELN).Prepare and deliver effective presentations to project stakeholders and the company's leadership team.Required Qualifications: PhD with 0-3+ years' experience; MS with 6-9+ years or equivalent industry experience.Strong background in RNA biology.Broad experience in molecular biology & cell-based techniques such as mammalian cell culture, transfections, DNA/RNA extraction, dPCR, RT-qPCR, gel electrophoresis, western blotting and NGS.Excellent attention to detail, time management, and documentation skills.Excellent communication skills and the ability to work independently and collaboratively.Ability to implement new techniques and balance multiple priorities.Other Knowledge, Experience or Skills recommended: Experience with oligonucleotide therapeutics is highly preferred.Experience with high-throughput liquid handling platforms is a plus.Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.
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