Job Description - Senior Data Scientist (2400036H) Description: Build scalable, production ready machine learning and statistical models to improve healthcare data latency through automation. This role will focus on advanced statistical and machine learning solutions collecting, cleansing, interpreting large volumes of data from varying sources, designing and delivering production ready models, monitoring and maintaining models' health in production, all while communicating key findings with stakeholders.
The Rokita Lab at Children's National Hospital is seeking a highly skilled Senior Bioinformatics Scientist to join our team. We are situated within the Center for Cancer and Immunology Research (CCIR) and Brain Tumor Institute. This position will play a critical role in advancing research focused on uncovering oncogenic mechanisms in pediatric brain tumors and identifying novel therapeutic targets through integrative genomics of host-tumor genome data. The Senior Bioinformatics Scientist will engage in translational research projects and contribute to tool development, such as interactive applications for visualizing complex genomic data.
The role involves close collaboration with researchers and clinicians within both Children's National as well as external partners. The successful candidate will lead independent bioinformatics-driven projects, mentor junior team members, and contribute to grant applications and scientific manuscripts.
Key Responsibilities: Lead bioinformatics analyses on pediatric oncology datasets, including genomic, transcriptomic, and epigenomic data.Design and implement downstream analytical workflows for high-throughput data using our GitHub, Docker, and AWS infrastructure, focusing on reproducibility, code efficiency, and scalability.Collaborate on the Open Pediatric Cancer (OpenPedCan) Project.Identify RNA neoepitope CAR-T or RNA vaccine targets, consisting of proteomic validation.Utilize cloud-computing environments (e.g., AWS EC2) and/or high-performance computing (HPC) to support large-scale or memory-intensive analyses.Actively and positively participate in sprints and code reviews, ensuring high standards for reproducibility and documentation.Engage with multidisciplinary teams, providing bioinformatics expertise to support collaborative research initiatives.Application Process: This position will be remote. Candidates should be prepared to share their GitHub handle and present a project as part of the interview process.
Qualifications Required Qualifications: Ph.D. in Bioinformatics, Computational Biology, or a related field, or equivalent industry experience.At least five years of experience in bioinformatics, with expertise in Bash, R or Python, RShiny and/or Python GUI applications such as Streamlit, NiceGUI, Dash, etc.Proficiency with cloud-based or high-performance computing environments for bioinformatics workflows.Strong experience with tools and best practices for reproducibility, including Git and Docker.Proven experience with genomic data types such as single nucleotide variants (SNVs), copy number variants, fusions, RNA expression, methylation, proteomics, and splicing data.Commitment to open science practices, including sharing and collaborating on code, data, and documentation.Knowledge of pediatric oncology and genomics.Preferred Skills: Strong organizational and project management skills, with the ability to work on multiple projects and teams.Excellent communication skills, with the ability to work in cross-disciplinary teams.Eligible to apply for young investigator grant funding.Primary Location: District of Columbia-Washington
Work Locations: CN Hospital (Main Campus) 111 Michigan Avenue NW Washington 20010
Job: Information Technology
Organization: Ctr Cancer & Immunology Rsrch
Position Status: R (Regular) - FT - Full-Time
Shift: Day
Work Schedule: 9:00-5:30 PM
Full-Time Salary Range: 109116.8 - 181854.4
Childrens National Hospital is an equal opportunity employer that evaluates qualified applicants without regard to race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law. The "Know Your Rights" poster is available here: and the pay transparency policy is available here: Know Your Rights Pay Transparency Nondiscrimination Poster. Please note that it is the policy of Children's National Hospital to ensure a "drug-free" work environment: a workplace free from the illegal use, possession or distribution of controlled substances (as defined in the Controlled Substances Act), or the misuse of legal substances, by all staff (management, employees and contractors). Though recreational and medical marijuana are now legal in the District of Columbia, Children's National and its affiliates maintain the right, in accordance with our policy, to enforce a drug-free workplace, including prohibiting recreational or prescribed marijuana.
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