Senior Director, Pharmacology

Senior Director, Pharmacology page is loaded Senior Director, Pharmacology Apply locations Boston, MA time type Full time posted on Posted 30+ Days Ago job requisition id REQ-23430 Job Description General Summary: Vertex is currently seeking an experienced leader with expertise in nonclinical pharmacology and drug development to lead the Preclinical Pharmacology team . The Senior Director, Pharmacology will lead a team of scie ntists who are responsible for the design, implementation and execution of in vivo pharmacology studies and ex vivo assays to support the advancement of Type 1 diabetes cell therapy programs to successful IND filing s . This includes design and execution of pharmacology assays to determine drug potency, efficacy and mechanism of action , the maintenance of structural organization within cross-functional teams , as well as the scientific and managerial coordination of personnel. In addition, t h is role will be responsible for integrating key functional workstr eams requ ired for nonclinical development of T1D-related cell therapies , including in vivo pharmacology studies and ex vivo biomarker analysis . The ideal candidate will have a clear track record of successfully leading pharmacology teams, a PhD in Pharmacology, Immunology, or a related biomedical discipline , demonstrated extensive experience within the diabetes disease area and/or cell therapies in the biopharmaceutical industry and have participated in preparation of regulatory filings.
Key Duties and Responsibilities: Leads all internal and external preclinical pharmacology activities supporting multiple Type 1 Diabetes (T1D) programs.Provides leadership, strategic oversight, organizational structure, and resource management of the pharmacology team. Contributes to a team culture that promotes collaboration and open communication with key stakeholders, internal teams and external partners to ensure alignment of research objectives. Develops team goals and ensures alignment to personnel goals in support of the corporate goals. Acts as subject matter expert as part of project team(s); communicating recommendations related to study plans, methods, analysis and timelines in a clear and timely manner. Monitors the activities of staff and provides reliable mentorship and guidance for them to succeed and grow. Ensures quality and integrity of all preclinical research activities. Manages resources, timelines and budget to support all internal and external nonclinical pharmacology activities. Knowledge and Skills: Ph.D. (or equivalent degree) in Pharmacology, Immunology or a related discipline and at least 11 years of relevant experience in the biopharmaceutical industry, or Master's Degree (or equivalent degree) in Pharmacology, Immunology or a related discipline and at least 15 years of relevant biopharma experience, or Bachelor's Degree (or equivalent degree) and 20+ years of relevant biopharma experience. Extensive experience in leading non-GLP and GLP studies and management of external studies contracted with CROs. Proven success and experience in preparing study reports and authoring regulatory documents (IND/CTA/IB/BLA) for submission to health authorities as part of regulatory filings is required. Prior experience managing a preclinical pharmacology team responsible for conducting small and large animal research. Experience in cell therapy and/or Type 1 Diabetes research and development Education and Experience: Effectively interacts with senior management and integrates activities across the organization . Exhibits an outstanding record in multiple development projects, enabling the success of others . Highly evolved understanding of pharmacology and other key scientific fields that impinge on primary area(s) of responsibility . Excellent business-oriented oral and written communication and presentation skills. Flex Designation:
On-Site DesignatedFlex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. 
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
Company Information Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ******
Similar Jobs (4) Clinical Development Senior Medical Director, T1D (Transplant Immunology/Endocrinology) locations Boston, MA time type Full time posted on Posted 30+ Days Ago Director, Clinical Pharmacology (Remote) locations Boston, MA time type Full time posted on Posted 30+ Days Ago Clinical Development Senior Medical Director, Hematology locations Boston, MA time type Full time posted on Posted 30+ Days Ago
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com  or follow us on Facebook , Twitter/X ,  LinkedIn ,  YouTube  and  Instagram . The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people's lives.  Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.

#J-18808-Ljbffr