Join our Mission to Protect Humankind!
Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.
WHAT
we do is every bit as important as
HOW
we do it!Our work together is guided by four enduring core values:
*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.
*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
Summary:
Vaxcyte is seeking a talented and experienced Engineer I, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team with a mission to establish a new cell-free protein synthesis (CFPS) process utilizing fresh extract at Vaxcyte.
The successful candidate will have the following skills and qualities:
·Experience with developing and optimizing CFPS processes.
·Strong knowledge of critical CFPS raw material production and testing.
· Experience mentoring junior scientists in the lab.
·Experience in small-scale to pilot-scale operations of CFPS.
·Skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization. Skilled at analyzing and presenting data from experiments, trials, and manufacturing runs to identify opportunities for process improvements, troubleshooting, and optimization.
· Experience in spent-media analysis to determine CFPS nutrient limitations.
·Background in fed-batch CFPS production.
·An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals.
·Strong organizational and planning skills.
Essential Functions:
· Develop, test, and implement recipe scripting for CFPS.
· Provide engineering support for selection, commissioning, and qualification of new CFPS-related equipment as well as scale-down models.
· Design and execution of upstream CFPS experiments in various platforms including plate-based assays and SUB pilot bioreactors.
· Author SOPs (standard operating procedure), process flow diagrams and batch records.
· Analyze and present CFPS data at internal project meetings. Participate in upstream database management and documentation in electronic notebooks.
· Develop CFPS scale-up/down models to support technology transfer and manufacturing activities.
· Knowledge of ambr-250 bioreactor system a plus.
Requirements:
· PhD in Chemical Engineering or a related discipline with 5+ years of relevant Pharma/Biotech industry experience, or MS in Chemical Engineering with 10+ years of relevant Pharma/Biotech industry experience.
· Strong background in cell-free protein synthesis.
· Hands-on experience with CFPS and primary recovery unit operations.
o Good understanding in fundamentals of bioreactor design, operation and controls.
o Strong knowledge of aseptic techniques.
o Mechanical and technical knowledge of primary recovery unit operations such as centrifugation, and depth filtration, is a plus.
· Familiarity with DoE (Design of Experiments) principles and software.
· Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus.
Reports to:
Staff Scientist, Upstream Development
Location:
San Carlos, CA
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range:
$74,000 – $90,000
Send resumes to:
********
Vaxcyte, Inc.
825 Industrial Road, Suite 300
San Carlos, CA 94070
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion,sex, sexual orientation, gender identity, national origin, disability or veteran status.
#J-18808-Ljbffr
