Precision for Medicineis the first global precision medicine clinical research services organization, purpose-built to improve the clinical research and development process for new therapeutics. With over 2,000 dedicated professionals and 35 offices worldwide, we stand ready to help accelerate life-changing treatments anywhere around the globe.
Precision for Medicineis recruiting new team members due to a major expansion at our Frederick, MD site! Our newly built, state-of-the-art 40,000 sq ft laboratory opened Q1 2024 and serves as a global center of excellence for gene therapy companion diagnostics, large molecule bioanalytical, immune monitoring, and cell biology assays. We are recruiting for aFlow Cytometry Principal Scientistto add to the Flow team in Frederick.
The Principal Scientist will be instrumental in helping Precision achieve its goals of delivering exceptional services to Precision's diverse, innovative and global biopharmaceutical clients. Working closely with the Senior Vice President, Lab Operations they will help implement the strategic scientific plan to support translational medicine research, primarily, but not solely, in the Immuno-Oncology and autoimmune/inflammatory space.
Key components will be focused on, design and development of innovative qualified and validated immunophenotyping (including high content flow cytometry assays up to 31 markers, receptor occupancy assays, tetramer/dextramer assays as well as immunophenotyping flow based assays), and antigen specific (ELISpot/Fluorospot) or other custom cell based assays.
The successful candidate will assist and be a resource for senior team members to design experimental plans and timelines, that match client specifications/requirements. They should and be able to communicate the plan and progress to the client, along with executing and reporting the work according to agreed timelines and under the appropriate regulations (GLP, CAP, CLIA etc.). A significant aspect of this job is the training and mentoring of more junior scientists and team members in bioservices both in laboratory techniques and in the analysis and presentation of data. The role will provide technical expertise to the laboratory as needed, as well as the expectation is that a large part of training is provided "hands on".
Essential functions of the job include but are not limited to:
Provide mentoring, coaching and team leadership to Flow Laboratory team members, hold one-on-one engagement meetings with direct reports, set goals, conduct performance reviews and set priorities for lab work
Motivate team, share knowledge on FACS, participate in recruitment process and revenue forecasting
Design and implement cell-based assays to meet client requirements; may include complex flow immunophenotyping assays, primary cell based assays.
Write and implement standard operating procedures (SOPs) to perform assays to meet client requirements and the level of regulatory compliance needed
Utilize current SOPs to perform cell assays such as flow immunophenotyping, ELISpot, and other custom cell based assays.
Generate technical reports and other communications required to present data to clients
Write posters and papers for submission to conference organizers and peer reviewed journals
Write reviews and white papers
On occasion, review and edit client proposals, contract/proposals as appropriate.
Train scientific staff in the review and presentation of data; including client reports, posters and papers for peer reviewed journals
Train technical staff how to perform laboratory procedures. Devise and perform validation schema to ensure staff are superbly trained and competent. Maintain and support safe lab practices and environment
Track and trend laboratory efficiency and quality
Perform duties with high degree of independence, quality, and efficiency
Act as internal expert on technical advances and industry trends to anticipate and act as a thought leader to management on all matters of major importance, initiate and/or recommend appropriate courses of action and identify those matters requiring policy interpretation or revision
Promote the company to local, regional, national, and international constituencies through networking, speaking engagements, activity in professional associations and publications
Qualifications:
Minimum Required:
Must have a Ph.D. in life sciences or relevant field (preferably Immunology, Cellular Biology)
At least 8 years of full-time post-doctoral laboratory experience
Other Required:
Strong bench scientist skills around cell based assays. Hands on flow cytometry experience is required. Preferably with experience in ELISpot and other cell based assays. Core competencies of standard biology laboratory experience e.g. cell isolation, and primary cell based assays.
Experience with cell sorting, trouble-shooting and client relationships, alliance partnerships and timelines
Experience in validation/qualification of assays to CAP/CLIA/GLP or ISO guidelines
Strong organizational skills
Strong communication skills
Experienced technical report generation
The ability to see and differentiate between colors on the full color spectrum
Ability to lift and carry between 1-15 lbs.; Ability to lift up to 50 lbs. overhead with assistance; frequently required to sit, grasp, and use right/left finger dexterity; May be exposed to a cold freezer environment (Freezer temperatures range between -20ºC -196ºC)
Must be able to read, write, speak fluently and comprehend the English language
Preferred:
10-15+ years' experience as CORE lab member with leadership role as direct manager to flow cytometry team
Industrial experience and/or management of outside collaborations is desirable
Experience with viral infections; cell culture and cell line derivation; nucleic acid (RNA & DNA) extraction from primary human samples; nucleic acid characterization by spectrophotometer, Agilent, and fluorescence-based detection
