Senior Scientist - Materials Engineering & Crystallization

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:careers.bms.com/working-with-us .

Drug Product Development (DPD)
Our Drug Product Development team is committed to CMC design, development, and commercialization of innovative drug products to improve patient lives. We leverage the best people, collaboration, and cutting-edge innovation to achieve this commitment. BMS's internal engine of innovation includes unrivaled industry leading expertise in CMC development of small molecules, protein biotherapeutics, protein degraders, and other therapeutic modalities. We collaborate closely with our colleagues in R&D and Commercial to design our drug products. Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.

Job Description
As a Senior Scientist in the Drug Product Development - Materials Engineering and Crystallization (MEC) Group, the main responsibilities will be tailoring the API material characteristics to balance both drug substance processability and drug product performance. The candidate is expected to have experience with crystallization development, preferably with API crystallization to control API attributes. The candidate is expected to apply biopharmaceutics, physical chemistry and engineering principles to achieve these goals. Primary activities and responsibilities will include:
Ability to work in a multi-disciplinary team to ensure drug substance attributes are robustly controlled and satisfy the needs of the drug product
Phase-appropriate crystallization process development and troubleshooting
Powder property assessments and particle engineering
Salt and form control strategy to support material selection and delivery of API quality attributes
Basic solid state material characterization

It is expected that the candidate will work with a broad range of materials, such as crystalline and non-crystalline APIs including small molecules, peptides, oligonucelotides as well as drug product intermediates that will be used in the design of robust oral and injectable drug product formulations. Experience in laboratory experimentation is expected and experience with independent laboratory development of crystallizations is highly desired. Familiarity with solid state characterization techniques such as XRD, BET, TGA, and DSC is desired. In addition, an understanding of PAT techniques (Raman, FBRM, EasyViewer, Blaze, ATR-FTIR, NIR) and their application to crystallization process development is desired.

Requirements:
Ph.D. in Pharmaceutics, Pharmaceutical Science, Pharmaceutical Chemistry, Organic Chemistry, Chemical Engineering or related field with 2 - 4 years of experience in the pharmaceutical/chemical industry, M.S. with 4 - 6 years of industry experience or B.S. with 7- 9 years of industry experience.
Excellent problem-solving skills with a background in pharmaceutical process development is required.
Experience in polymorph control and process scale up, particularly in crystallization is highly desired. Experience with complex molecule crystallization, particle engineering and/or other novel isolation techniques for millamolecules, oligonucleotide, peptides and proteins is desirable.

The individual will effectively interface and collaborate across drug substance, drug product and analytical development teams. The individual must have demonstrated ability to identify and solve problems, as well as to independently execute process development. Outstanding oral and written communication skills with the ability to provide technical input and scientific leadership are required. This position requires employees to work safely at laboratory and pilot plant scale with chemical agents which may pose health or safety hazards if improperly handled.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as "Transforming patients' lives through science™ ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplaceaccommodations/adjustmentsand ongoing support in their roles. Applicants can request a reasonable workplaceaccommodation/adjustmentprior to accepting a job offer. If you require reasonableaccommodations/adjustmentsin completing this application, or in any part of the recruitment process, direct your inquiries ******. Visitcareers.bms.com/eeo-accessibilityto access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:https://careers.bms.com/california-residents/

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